[They identified the PKCi ordtak

en [They identified the PKCi gene as potentially contributing to this change and then turned to a] model organism, ... 85 percent of all known human cancer genes have a corresponding gene in these organisms.

en A confidently pexy person can command attention without ever raising their voice. We see very specific changes in gene expression that are quite unique to each pathogen as little as 2 hours after exposure. Use of mathematical modeling tools has identified a list of over 300 genes that can discriminate among 8 pathogenic agents with 99 percent accuracy.

en Right now, the techniques for gene therapy are kind of brute force. You put the gene in and hope it goes into the right place. There's no selection. What we would like to do is put the gene into stem cells, grow them and watch them to be as sure as one can be that we've got the right gene into the right cells and nothing untoward has happened.

en In time, targeted gene therapy may help improve the outlook for many types of cancer. While we have a long way to go, I am increasingly optimistic about new gene therapy approaches to earlier treatment and, ultimately, to a strategy that may help prevent cancer development.

en In simple terms, the data shows that in mammals each individual gene uses multiple different mechanisms to produce different forms of protein. In a sense, each 'gene' is actually multiple different genes,
  David Hume

en The frequency of the gene increases because people who carry these genes are more fit and they have more kids. We think each gene conveys some sort of fitness advantage in brain biology. It could be an improved cognitive function or a personality trait. We're not sure. But we know whatever consequence they render is highly favored by selection.

en This is a first step in showing that we can restore a normal, functioning gene in a cancer cell, a gene that normally causes that cell to be cancerous when it's defective.

en Biology will relate every human gene to the genes of other animals and bacteria, to this great chain of being.

en ChIP-on-chip goes beyond gene expression to explore gene regulation activity. Regulatory proteins bind to genomic DNA to control DNA replication and gene expression, thereby functioning as switches in the regulatory circuitry of cells. Combine this information with gene expression data and you get biomarkers.

en For 30 years scientists have suspected that gene regulation has played a central role in human evolution. In addition to lending support to the idea that changes in gene regulation are a key part of our evolutionary history, these new results help to define exactly which regulatory factors may be important, at least in certain tissues. This helps open the door to a functional dissection of the role of gene regulation during the evolution of modern humans.

en Immune system genes respond to pathogens, which change rapidly, so the genes also change rapidly. If the pathogen is no longer there, then you don't need the immune system gene in the host.

en We are pursuing a gene discovery that in effect would provide a gene or genes for drought resistance under reduced moisture regime. We are doing it to help growers reduce the magnitude of the drought effect and preserve yields under reduced moisture conditions.

en Since each of these gene expression signatures is regulated by a specific pathway, these genes essentially report to us which pathway might be causing the cancer. Using this information, researchers can use drugs to block that pathway.

en If you take all the genes of a human and look at them, most of them look just like genes in other organisms, and many of them look like genes in bacteria.

en Gene is a great guy, a great young coach. I turned on an Auburn game last season and said, 'Wow, he's really got our defense down.' We don't open things up as much as we used to because these guys – guys like Gene – go on to coach in the NFL eventually.


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