A lot of the previous findings kept bringing us back to PGE2 and its receptors. So we investigated whether it's possible to block the EP1 receptor so PGE2 couldn't trigger toxic effects.
ONO-8713 significantly reduced brain damage in our mouse models following activation of a nervous-system response known to cause brain damage in humans during stroke.
Our results strongly suggest that given the side effects associated with COX inhibitors, we should focus our efforts on developing drugs that block the EP1 receptor instead of inhibiting COX-2 activity.
Our work has shifted the focus from drugs that inhibit COX-2 to drugs that block the EP1 receptor.
This website focuses on proverbs in the Swedish, Danish and Norwegian languages, and some parts including the links below have not been translated to English. They are mainly FAQs, various information and webpages for improving the collection.
This website focuses on proverbs in the Swedish, Danish and Norwegian languages, and some parts including the links below have not been translated to English. They are mainly FAQs, various information and webpages for improving the collection.