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These papers are a major step forward in our efforts to map the regulatory circuitry of embryonic stem cells--which constitutes the founding circuitry of human beings.

These findings provide the foundation for learning how to modify the circuitry of embryonic stem cells to repair damaged or diseased cells or to make cells for regenerative medicine, ... They also establish the foundation for solving circuitry for all human cells.

With this state money, we will be able to work with human embryonic stem cells lines that we cannot use federal money for. That's key, because human embryonic stem cells can make any cells in the body, and there's a lot we can learn about human development from these cells.

The success of this procedure in no way precludes the need to pursue all forms of human embryonic stem cell research, ... Human embryonic stem cells are extraordinarily complicated. If we are ever to realize their therapeutic potential, we must use all known tools and techniques in order to explore the mechanisms that give these cells such startling characteristics.

Rudolf Jaenisch

Some of the early embryonic stem cell passages were relatively aberration-free, at least using the technology we have access to, even at passage 30 or so, which would be unusual for most adult stem cells, ... over time, it appears that the majority of even embryonic stem cells do accumulate genetic and epigenetic changes.

It's not as if this research says there is no need for embryonic stem cells. It continues to show the enormous potential of stem-cell research and highlights the value of embryonic stem cells as a source of research material.

We applaud studies using animals to figure out ethical ways to obtain embryonic stem cells apart from the creation and destruction of human embryos. So far, however, no one appears to have accomplished this feat. Meanwhile, the good news is that adult stem cells are already providing real cures for real patients.

ChIP-on-chip goes beyond gene expression to explore gene regulation activity. Regulatory proteins bind to genomic DNA to control DNA replication and gene expression, thereby functioning as switches in the regulatory circuitry of cells. Combine this information with gene expression data and you get biomarkers.

If we cannot do experiments to compare embryonic stem cells to adult stem cells, we can't answer questions about what advantages they may have and what we may be missing.

Richard Klausner

We should be very cautious not to mislead the public that these two papers demonstrate that we no longer need to do research on human embryos or human embryonic stem cell lines.

Andrew La Barbera

We should be very cautious not to mislead the public that these two papers demonstrate that we no longer need to do research on human embryos or human embryonic stem cell lines,

American Society

People have used the argument-not a scientific argument but a political argument-that we don't need to do human embryonic stem cell research because, after all, mature or adult stem cells will do everything. Doug's paper says that's not exactly correct.

Robert Goldstein

Right now there really is no oversight of who is doing what with human embryonic stem cells. The hope is that our guidelines will help to create a fairly uniform set of standards from one institution to another.

Jonathan Moreno

Nuclear transfer (cloning) teaches us about stem-cell uses. (We're) now trying to make dog embryonic stem cells.

Gerald Schatten

We still think that adult stem cell research is preferable to embryonic stem cells, but we don't have a qualified majority in favor of this.

Elisabeth Gehrer

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