We've engineered them to ordspråk

We've engineered them to have a bovine gene. In that way they've now become susceptible to mad cow disease,

The aim is to identify DNA variants which play a role in susceptibility or resistance to these diseases. There may be variants that make it more likely that you will get type 2 diabetes, and other variants that have a protective effect against the same disease. With most of these diseases, we understand little about the causes. If we can learn that this gene makes you more or less susceptible, we get important clues as to how the disease works.

If we can find drugs that increase activity of the DJ-1 gene, we may be able to stop the relentless progression of Parkinson's disease even in patients who don't have mutations in the gene. Stopping a disease in its earliest stages would be a tremendous breakthrough.

If we can find drugs that increase activity of the DJ-1 gene, we may be able to stop the relentless progression of Parkinson's disease even in patients who don't have mutations in the gene. Stopping a disease in its earliest stages would be a tremendous breakthrough.

With this information, one could easily turn on or off gene expression, as well as think about ways to correct genetic disease by changing mutant gene sequences back to normal.

Our research shows how a genetic cause of Parkinson's disease works. We show how the normal function of the gene keeps dopamine cells from dying. If the gene is abnormal, these protective mechanisms cannot be brought into play.

Our research shows how a genetic cause of Parkinson's disease works. We show how the normal function of the gene keeps dopamine cells from dying. If the gene is abnormal, these protective mechanisms cannot be brought into play.

Right now, the techniques for gene therapy are kind of brute force. You put the gene in and hope it goes into the right place. There's no selection. What we would like to do is put the gene into stem cells, grow them and watch them to be as sure as one can be that we've got the right gene into the right cells and nothing untoward has happened.

Eventually, that's where engineered mice are going. That's a more realistic disease model.

What's new here is not the use of umbilical cord blood in the treatment of a life-threatening disease, but it's the way the transplant was engineered and the way the baby was conceived.

While scientists have believed that aging is a disease in which cells stop dividing, this study suggests that aging is really a disease of quality control. In this case, the manufactured product is a new cell. As we get older, altered gene expression results in cells with diminished function.

ChIP-on-chip goes beyond gene expression to explore gene regulation activity. Regulatory proteins bind to genomic DNA to control DNA replication and gene expression, thereby functioning as switches in the regulatory circuitry of cells. Combine this information with gene expression data and you get biomarkers.

People with Parkinson's disease also become more susceptible to falls, which can result in a higher risk of fractures.

Mohammad Alhalabi

It is not likely one gene will explain the whole disease, but [this research] is so intriguing because it potentially provides a novel therapeutic approach, not just a genetic linkage.

Insurance is so huge. This is labeled a rich girl's disease. All young women are susceptible, but only a few people can afford the treatment that is needed.

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