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This will be the most powerful genetic study that has ever been undertaken for MS or for any other disease.

These offspring have what we have called 'occult' genetic disease -- their genetic make-up is perfectly normal, but they still have the physical problems of their parents. This phenomenon could complicate the hunt for disease genes.

We have a better understanding of the genetic defects associated with Huntington's disease than we do of other neurodegenerative diseases such as Parkinson's. Establishing this nonhuman primate model for Huntington's disease is critical to providing a foundation for studying the genetic causes of other neurodegenerative diseases.

These new findings offer, for the first time, compelling genetic evidence that myelin breakdown underlies both the advanced age and the principal genetic risks for Alzheimer disease.

Dr. George Bartzokis

If you were to search for the genetic mutation behind this mouse's disease, you wouldn't find it; there isn't one. These mice develop disease only because their telomeres are short, and having telomerase doesn't lengthen them right away.

We've translated early information from genetic research into valuable medicines for HIV/AIDS, heart disease and the prevention of organ rejection. But these advances have only scratched the surface of possible revolutionary approaches to treat and cure diseases. Pfizer, the NIH and other public/private biomedical research interests have complementary missions greater than the sum of their parts. Our hope is that this public/private initiative will encourage a deeper collective understanding of the genetic factors of disease for major new therapeutic advances.

This is a terrible disease whose causes have remained unclear and for which no treatment exists, ... Our findings provide convincing support for a genetic basis. But it's more than that -- development of the disease takes a second hit. One such hit is cigarette smoking.

We've translated early information from genetic research into potentially valuable medicines for HIV/AIDS, heart disease, and prevention of organ rejection, but these advances have only scratched the surface of possible revolutionary approaches to treat and cure diseases. Pfizer, the NIH and other public/private biomedical research interests have complementary missions greater than the sum of their parts. Our hope is that this public/private initiative will encourage a deeper collective understanding of the genetic factors of disease, for major new therapeutic advances.

It is somewhat of a rare genetic disease,

The hundreds and hundreds of African-American women participating in the Carolina Breast Cancer Study made this discovery possible. Their willingness to take part in this outstanding population-based study and contribute DNA for genetic analysis is a remarkable legacy.

Neurodegenerative diseases like Huntington's disease are complex disorders that involve genetic defects and physiological changes including the death of neurons that lead to a wasting away of the brain, ... Because of their genetic and behavioral similarities with humans, transgenic nonhuman primate models will allow us to clarify the correlation between defects and neurological changes caused by neurodegenerative diseases.

We don't yet know what factors determine whether people with this genetic variation do or don't end up with dyslexia, ... A host of environmental and genetic influences likely influences or determines whether somebody with this particular genetic variation ends up being dyslexic or not. And until the nature of some of those other influences is fully specified, we won't know what it means to say to somebody that their 5-year-old child has this particular genetic endowment.

PAT committed to have such a study undertaken years ago. Now that this funding has been approved, they will go forward with that.

Our research shows how a genetic cause of Parkinson's disease works.

Our research shows how a genetic cause of Parkinson's disease works.

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