Although these results are in mice, not people, they raise an exciting possibility which can be tested in humans. |
I think aspirin would do exactly what you might expect -- attenuate, but not abolish the risk. |
Lots of genes could be important -- genes that determine how you absorb a drug, variations in one gene involved in breaking down the drugs, variations in the way that you excrete a drug. |
One of the surprises in this study, where we put some of the people through the same protocol five times, is that there is substantial variation with a person on how they respond day to day. That can be due to a lot of potential sources, including environmental factors, that we don't understand. |
Up until now we have chronically underestimated the very substantial differences in the way individuals respond to the same dose of the same drug. |